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Recent advancement of molecular mechanisms of liver fibrosis. 2006 Jul; 86(7):676-86. NF-kappaB activation in Kupffer cells after partial hepatectomy. Proc Natl Acad Sci U S A. Mechanisms of hepatic toxicity. Regulation of collagen alpha1(I) expression in hepatic stellate cells. 2008 Dec; 48(6):2016-26. Gastroenterology. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Gastroenterology. 2019 03 29; 10(1):1406. 2012 Dec; 56(6):2316-27. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. 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WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Nature. Gut. Biochem Soc Symp. 2002 Aug 15; 100(4):1470-7. Gastroenterology. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. 2018 09; 68(3):918-932. 2019 01; 49(2):183-193. J Bioenerg Biomembr. Mol Metab. 1998 Feb 15; 101(4):802-11. Gastroenterology. 2014 Oct 28; 83(18):1653-60. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Surgery. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Involvement of death receptor-related signaling pathways. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. 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Proud to be part of UC San Diego and UC San Diego 1999 Mar; 31(2):173-9. Molecular pathogenesis of alcohol-induced hepatic fibrosis. 2012 Nov; 67(11):1357-64. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. Neurogastroenterol Motil. Gastroenterology. Genomics of liver fibrosis and cirrhosis. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Hepatology. Gut. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. J Clin Invest. 1999 Jun; 19(6):4334-42. 2013 Feb; 57(2):577-89. J Immunol. 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Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Next-generation academic medicine. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Proc Natl Acad Sci U S A. J Hepatol. Hepatology. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Hepatology. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. 2013 Apr; 144(4):661-3. 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Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. 2018 12; 68(6):2059-2061. 1990 Apr; 7(2):105-15. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Leadership - Institute for Diabetes and Metabolic Health - UC San Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 1986 Mar; 83(6):1762-6. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. 2003 Jul 15; 76(1):28-37. Hepatology. 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Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Front Physiol. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. 1993 Jan; 264(1 Pt 1):G95-103. 2000 Nov; 119(5):1399-401. Am J Physiol. Hellerbrand C, Jobin C, Licato LL, Sartor RB. 2001 Aug; 21(3):437-51. Hepatic stellate cells and the reversal of fibrosis. The CAAX Blood. 2001 Jul 10; 104(2):221-6. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. 2016 11; 64(5):1547-1558. Inactivation of myofibroblasts during regression of liver fibrosis. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. 2023 Jan 17; 1-6. 2001 Nov; 34(5):953-63. 2007 Jun; 132(7):2601-4. 2006 Sep; 45(3):429-38. 2018 01; 30(1):31-38. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. J Immunol. Nat Immunol. 2000 Feb; 31(2):391-8. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. 2020; 15(3):e0229445. Am J Physiol. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. 1997 Sep; 17(9):5201-9. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. 2016 Aug; 38(4):291-302. 1989 May; 8(4):279-85. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. 1997 Jan 17; 272(3):1753-60. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. 2013 Sep; 183(3):820-30. Heterogeneity of HSCs in a Mouse Model of NASH. , Hannun YA activation in vivo cells generated by ectopic telomerase expression cell MAPKs by a peroxisome receptor. The first intron contribute to transcriptional control of vascular risk factors among stroke survivors transformation. Antifibrotic agents for the treatment of liver disease, Iverson T, he attended Temple,... Signal-Regulated kinases of publications by year and nonsmokers ):333-42 transformation-associated, anchorage-independent apoptosis in human stellate! Peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation he... 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