Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. The authors used a cancerous liver cell line. Huh7, MeSH Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. Indeed, if you look at the article in the journal in which it was published. Accessibility PMC However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. WebPfizer Vaccine Becomes DNA in Liver Cells. 5. For general inquiries, please use our contact form. In part III of this series, we will dive more deeply into some of the things to look for when evaluating claims about a specific study. DNA, contained in all cells, is the building block of the bodys genetic code. As such, consumers of information should always consider messages with a questioning attitude. Said another way, it was an . The persistence of the spike protein in the body raises the prospect of sustained inflammation within and damage to organs which express the spike protein, according to experts atDoctors for COVID Ethics,an organization consisting of physicians and scientists seeking to uphold medical ethics, patient safety, and human rights in response to COVID-19.. All quotes delayed a minimum of 15 minutes. Likewise, the Results section has five sentences. Pfizer Vaccine Becomes DNA in Liver Cells. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: This article was produced by the Reuters Fact Check team. Pfizer-BionTech Vaccine DNA in Liver Cell Nucleus (In-vitro Swedish Study)\r\rAn accepted and published Swedish study demonstrates for the first time the presence of Pfizer-BionTech vaccine DNA in the cell. Bethesda, MD 20894, Web Policies We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. or, by Lund University. Further proof with COVID-19. Cells that received no vaccine at all were used for control purposes.The researchers then investigated how different gene expressions in the cells changed over time. The messenger RNA (mRNA) from Pfizer s COVID-19 Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. Our monetization model empowers Citizen Journalists to report the news in local and national markets. We show that the vaccine enters liver cells as early as 6 hours after the vaccine has been administered. part may be reproduced without the written permission. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. YDM: More research is needed. But the study did not demonstrate that anything further happened with the converted DNA. The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. A gene that the researchers studied produces the protein LINE-1. PCR on genomic DNA of Huh7 cells exposed to BNT162b2 amplified the DNA sequence unique to BNT162b2. Click here to sign in with BNT: BNT162b2; L: DNA ladder; Ctrl1: cultured Huh7 cells; Ctrl2: Huh7 cells without BNT162b2 treatment collected at 6 h; Ctrl3: Huh7 cells without BNT162b2 treatment collected at 24 h; Ctrl4: Huh7 cells without BNT162b2 treatment collected at 48 h; Ctrl5: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h; Ctrl6: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h, digested with RNase. WebPrevious vaccines were largely attenuated or live vaccines that were bioengineered to not cause as severe of a reaction while still being similar enough to the origin virus to cause us to gain immunity. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. Read more about our fact-checking work here . YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. WebRead about Pfizer Vaccine Becomes DNA in Liver Cells. HHS Vulnerability Disclosure, Help Greece leads the car sales race in the EU! Additionally, the mRNA vaccine does in fact travel to the liver and other locations such as ovaries. Pfizers COVID trials6 enrolled 46,331 participants in a Phase 3 clinical trial while Recombivax HB tested just 147 infants and children. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. Microbiol Spectr. The posts share articles such as ones archived (here) and (here) saying the study, which was published in the Current Issues in Molecular Biology, shows mRNA from the Pfizer COVID-19 vaccine can enter human liver cells and convert to DNA as quickly as six hours after receiving a dose. 2021 Jun 7;22(5):172. doi: 10.1208/s12249-021-02058-y. 41.2M. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. The study authors, in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. It is reverse transcribed by LINE-1 proteins of the cells. The more virus in a sample, the fewer cycles it would take to detect RNA. Well do this by highlighting a few papers that caused fear, generated confusion, or spread misinformation by looking at the interpretation, what it was based on, and why it was not correct. The clip comes from a longer roundtable discussion that was posted March 8 by Christian broadcasting network Daystar, during which faith leaders discussed COVID-19 vaccines with the doctors. Sudden deaths of Canadian YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. The claim was also debunked by fact checker Health Feedback, which delved into the scientific claims in more detail (here). An important thing to notice when looking at this figure is that unlike most axis numbers, those on the y-axis showing cycle threshold are decreasing in number as they go higher on the graph. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. official website and that any information you provide is encrypted followers 26 videos. The messenger RNA (mRNA) fromPfizersCOVID-19vaccine is able to enter humanlivercells and is converted intoDNA, according to Swedish researchers at Lund University. doi: 10.1056/NEJMc2107717. As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. The mRNA then leaves the nucleus and enters the cells cytoplasm, where it translates into LINE-1 protein. Shakira. The pharmaceutical industry is dangerous to health. Cells that received no vaccine at all were used for control purposes. Researchers found that the entire process of the Pfizer COVID vaccine becoming DNA in liver cells took about six hours. Epub 2022 Nov 10. And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. These insects are generally larger in temperate areas than in the tropics. As such, even a rather long stretch of shared amino acids is not going to make two proteins automatically recognizable by the same antibodies because one or the other of the similar portions may be hidden within the 3D shape. Three other points about this paper are worth noting: Misclassification of study and logical fallacies (hasty generalization and appeal to ignorance). The study authors similarly pointed out in their Q&A that a limitation of their study is that they dont know if what we observed in this cell line could also happen in cells of other tissue types. They stated that this would need to be addressed in follow-up studies. The whole process occurred rapidly, within six hours, concluded the study, which was published by the universitys Department of Clinical Sciences. Montoya JG, Adams AE, Bonetti V, Deng S, Link NA, Pertsch S, Olson K, Li M, Dillon EC, Frosch DL. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. We show that the vaccine enters liver cells as early as six hours after the vaccine has been administered. Reuters has previously fact checked the claim that mRNA vaccines alter human DNA (here), (here), (here) and (here). More than 215 million or 64.9 percent of Americans are fully vaccinated as of Feb. 28, with 94 million having received a booster dose. It is the three-dimensional (3D) structure. A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage And even if there was, what are you going to do with 147 kids' data?7 MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. Childrens Hospital of Philadelphia is a charitable 501(c)(3) nonprofit organization. BNT162b2; COVID-19 mRNA vaccine; Huh7; LINE-1; liver; reverse transcription. Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination by ChAdOx1nCov-19. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. is the set of instructions to build and sustain a human being. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. Below Australian experts address this concern Expert Comments: Professor Nigel McMillan Program Director of Infectious Diseases and Immunology at the Menzies Health Institute Queensland , Griffith "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. Rasmussen also said, cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans.. time: 15 Cooks in: 1:40 Ready in: 1:55 Ingredients 1 kg beef flatiron 4 tbsp extra-virgin olive oil 1 garlic clove, finely chopped 1 tbsp tomato paste cup []. Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. , conducted by researchers at Lund University in Sweden and published in a peer-reviewed journal, investigated the effect of Pfizers mRNA COVID-19 vaccine on a human cell line that was derived from liver cancer tissue. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. in In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more About this website It only presents the body with the instructions to build immunity.. (In DNA amplicons (444 bps) were visualized on agarose gel. Bad Bunny. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. If you dont have time (or interest) in reviewing the primary source of the information, it is often best to let the information die in your feed or your inbox. First, cancerous cell lines replicate, whereas our liver cells typically are not replicating. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity, including whole genome sequencing of cells exposed to BNT162b2, as well as tissues from human subjects who received BNT162b2 vaccination, the authors said. Experts say that such interpretations mischaracterize the work and come to inaccurate conclusions. Webhttps://lnkd.in/dSz2cbQJ This was what everyone told me would not happen- that the RNA vaccines would not go into the DNA! Huh7 cells, Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 [hours] after BNT162b2 exposure.. Illustration of BNT162b2 was adapted from previously described literature [34]. doi: 10.7759/cureus.32361. Therefore, most scientists were critically monitoring data for any potential issues as COVID-19 vaccines were developed. selenagomez. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. Illustration, BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. WebThis and similar observations caused Spanish scientists to become curious about that actual contents of the vaccinations, since they wanted to understand what was giving rise to the magnetic effects. APS ASSESSMENT: False. doi: 10.1056/NEJMoa2034577. This paper suggested that COVID-19 vaccines that cause antibody production may cause a condition known as antibody-dependent enhancement (ADE). 2022 Dec 9;14(12):e32361. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. N. Engl. THE FACTS: Social media users are citing a study from Sweden that was published in February to push the unproven theory that mRNA COVID-19 vaccines permanently alter recipients DNA. -, Walsh E.E., Frenck R.W., Jr., Falsey A.R., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Mulligan M.J., Bailey R., et al. YDM: The attention of the media and the general public reflects a concern among some regarding new vaccine technologies. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. This is important for two reasons; both of which were acknowledged by the authors. 2022 Feb 28;194(8):E297-E305. While that point alone is enough to confirm that this paper does not offer evidence that COVID-19 vaccines cause ADE, it is also worth noting that the Methods section of the paper contains only five sentences, and the author describes looking at online protein banks and comparing the SARS-CoV-2 spike protein sequence to sequences of other proteins. This has been the question our study aims to answer. The Food and Drug Administration has flagged Guillain-Barre syndrome, a rare neurological condition, as a potential risk for Pfizers respiratory syncytial virus vaccine. 8600 Rockville Pike If you take just one thing away from this series, we hope you will have come to realize that science does not easily fit into a sound bite and, most often, it is not an either-or proposition, so if something sounds too simple, you probably need to ask more questions. The results have in many cases been misinterpreted, the Q&A also stated. Two years later, we have ample evidence that previously infected or previously vaccinated people do not get more severely ill. A look at the authors affiliation and declaration of competing interest as well as an online search of his name and place of employment indicate that he probably has an anti-vaccine bias. 2020;586:589593. In this case, the author compared gene sequences to identify sections of human proteins that have portions similar to SARS-CoV-2 proteins and made a prediction that the similarities would cause immune responses against oneself. badbunny. Pfizer Vaccine Becomes DNA in Liver Cells. RNA was purified and qPCR was performed using primers targeting BNT162b2. The spike protein naturally occurs on the outside of the virus that causes Covid. 2022 Apr 11;44(4):1661-1663. doi: 10.3390/cimb44040113. 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