Intermittent fasting also may improve the body's response to a hormone called insulin. To determine the effect of the IF diet on glucose metabolism, the study also investigated people with diabetes. Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice. WebPomegranate Pomegranate is one of the best foods that unclog arteries naturally. To induce myocardial infarction, the rats left coronary artery was ligated. A team of heart experts at Johns Hopkins has found that dual lab tests of blood clotting factors accurately predict the patients whose blood vessels, in particular veins implanted to restore blood flow to the heart during coronary artery bypass grafting (CABG), are more likely to fail or become clogged within six months. Also called bad cholesterol. The European Union on Tuesday extended a 610 million euro ($647.15 million) grant to Serbia for the construction of a fast railway line that will connect southern Serbia with central Europe. It exhibits anti-atherosclerotic and anti-inflammatory effects by inhibiting the adhesion of monocytes to endothelial cells. Wiciski M., Malinowski B., Wclewicz M.M., Grzek E., Grzek G. Resveratrol increases serum BDNF concentrations and reduces vascular smooth muscle cells contractility via a NOS-3-independent mechanism. Cardioprotective effects of the ADF diet are probably associated with a reduction of fat tissue (especially visceral fat tissue), increased adiponectin concentration, and decreased leptin and low-density lipoprotein (LDL) concentration [13]. These results demonstrate the effectiveness of weight loss despite the simultaneous intake of high-fat and sugar foods [26]. We need to stop looking at cholesterol as this dangerous substance in our body, the source of the problem comes from our diet and the way we eat, cholesterol and calcium plaques are simply consequences of this, not causes. After eating a meal, the concentration of glucose in the body increases and then within a few hours, it returns to the state it was before the meal. M.M.S., M.S. The study included 16 obese people12 women and 4 men. Fasting may be dangerous and it is not recommended for people with hormonal imbalances, pregnant and breastfeeding women, and diabetics. Its not only the best way to unclog arteries, but its simply the best way to prevent many diseases and problems like obesity, diabetes, fatty liver, etc. For 30 days, the animals were exposed to starvation during the night or had a limited food supply. In the elderly, it is associated with an increased risk of cardiovascular disease, arrhythmia, and stroke. Intermittent fasting methods include: Research on intermittent fasting is mixed. The researchers documented that the polyphenol rich juice supplement successfully lowered the total cholesterol values and LDL-C in serum in addition to the cholesterol concentration in the liver. Screenings of newborns and athletes for genetic heart disease. They migrate to the inner membrane of the vessels and are converted into macrophages [36]. After 4 weeks of diet use, a decrease in body weight and body fat content was observed in all experimental groups compared to the control group. The mechanism of this phenomenon is related to the protective action of the brain tissue against oxidative stress, and it was proven that the diet regulates many neuroprotective proteins present in the mouse brain after stroke. The Diabetes Remission Clinical Trial (DiRECT): Protocol for a cluster randomised trial. Another hypothesis is the impact of autophagy on beneficial effects of the IF diet in diabetic patients. Grapes are rich in resveratrol, which is why the largest concentration is found in red wine, but it is also found in blueberries, peanuts, and pistachios [80]. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Braun M., Pietsch P., Felix S.B., Baumann G. Modulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 on human coronary smooth muscle cells by cytokines. Ad libitum food intake in specific timeframe (~12-h). American Heart Association Nutrition Committee. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. LDL Cholesterol, for Low-Density Lipoprotein, is the one thats found in clogged arteries, meaning high LDL causes more cardiovascular complications. This concentration increased by 245%. For example, in studies conducted by Okamoto et al., using reverse transcriptase polymerase chain reaction (real-time) and ELISA testing, it was demonstrated that adiponectin has anti-inflammatory activity in human macrophages by inhibiting the production of CXC 3 receptor chemokine ligands. Kris-Etherton P.M., Harris W.S., Appel L.J. Vitamin K2 is a fat-soluble vitamin, so basically it is found only in good fat. Leslie W.S., Ford I., Sattar N., Hollingsworth K.G., Adamson A., Sniehotta F.F., McCombie L., Brosnahan N., Ross H., Mathers J.C., et al. Effect of Intermittent Fasting during Ramadan on Visfatin, Adiponectin and Tumor Necrotizing Factor-Alpha In Healthy Muslim Individuals. At the final time-point of week 50, weight loss was 5.2% 1.2% with ICR, 4.9% 1.1% with CCR, and 1.7% 0.8% with the control regimen (poverall = 0.01, pICR vs. CCR = 0.89). Further study is needed to understand the long-term effects. The mechanism of low blood pressure associated with the activation of the parasympathetic system is based on the increased activity of the cholinergic neurons of the cerebrospinal stem [19,60]. Wilson R.A., Deasy W., Stathis C.G., Hayes A., Cooke M.B. The human body is naturally adapted to such periods of fasting and in the moment of starving, adaptation mechanisms are used to obtain energy. 3. But most of the time, it comes down to reducing sugar and refined carbohydrates, eating vitamin-packed food, getting the right minerals, not shying away from fat, getting organic food and exercising. Despite the intermittent fasting diet having many benefits, its disadvantages are not without significance. determined the effect of a long-term high-fat diet (HFD) and an IF diet on the hearts of mice. The reduced amount of food consumed when using the IF diet results in a decrease in body weight. Sahebkar A. The effects of the IF diet on body weight and LDL cholesterol levels have also been proven in studies conducted by Wilson et al., on 8-week-old mice (39 males and 49 females). After a few weeks of observation, a decrease in SBP and DBP blood pressure was noted, as well as a reduction in heart rate [59]. All mice responded to atenolol with a reduction in heart rate. Let me explain. Sick fat, metabolic disease, and atherosclerosis. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Consumption of spirits should be limited to 10 g/day in women and 20 g/day in men [5]. The mortality rate is different in both sexes in any given period of life. K1 on the other hand, which can be found in soybean or canola oil did not. Investigators randomly assigned 150 overweight and obese nonsmokers to the ICR/5:2 group (5 days without energy restriction and 2 days with 75% energy deficit) and the CCR group (daily energy deficit 20%), or a non-intervention group (control groupwithout energy restriction). Polyphenols also contribute to the reduction of the lipid profile. Mayo Clinic does not endorse companies or products. LDL cholesterol is found in clogged arteries, so is calcium. Both groups were given anti-sympathetic drugs, atenolol, and anti-parasympathetic drugs, atropine. Ofori-Asenso R, et al. Sitting risks: How harmful is too much sitting? This can result in a heart attack. Supplementation of unsaturated fatty acids reduces the concentration of triacylglycerol from 25% to 30%, but can increase the concentration of LDL cholesterol in serum [90]. Malinowski B, et al. It may be used in three variants: 16/8, 18/6 and 20/4. Can vitamins help prevent a heart attack? The intermittent fasting diet causes an increase of BDNF factor, which results in lowering the systolic and diastolic blood pressure by activating the parasympathetic system. sharing sensitive information, make sure youre on a federal World Health Organization. Resveratrol inhibits hypercholesterolemia development. Harvie M.N., Pegington M., Mattson M.P., Frystyk J., Dillon B., Evans G., Cuzick J., Jebb S.A., Martin B., Cutler R.G., et al. on rat models with a high-fat diet. Rahimi-Ardabili B., Argani H., Ghorbanihaghjo A., Rashtchizadeh N., Naghavi-Behzad M., Ghorashi S., Nezami N. Paraoxonase enzyme activity is enhanced by zinc supplementation in hemodialysis patients. Miller M.E., Williamson J.D., Gerstein H.C., Byington R.P., Cushman W.C., Ginsberg H.N., Ambrosius W.T., Lovato L., Applegate W.B., ACCORD Investigators Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD Trial. This The Open Group OG0-093 online practice test engine helps you to familiarize yourself with the OG0-093 TOGAF 9 Combined Part 1 and Part 2 exam format I read, listened to or watched since I first started intermittent fasting in 2007.I hope these articles will help you ! ); lp.nelt@aksreisew.akna (A.W. It involves taking a normal, daily caloric intake with the use of short, strict calorie restriction [10]. Wang et al. official website and that any information you provide is encrypted They compared the starting concentration of adiponectin with the concentration observed after one year of a diet and increased physical activity. To examine the results of the right diet on the state of your arteries, you could ask your doctor to do a CAC check, for Coronary Artery Calcium. Such disturbances may cause menstrual cycle disorders in women and reduced testosterone in men. The trial included two phases: 6-month weight loss and 6-month weight maintenance. There are two subtypes of stroke: Ischemic stroke and hemorrhagic stroke. I offer my body to You as a living sacrifice daily in Jesus name. Adiponectin fulfills its functions by acting on adiponectin receptors found in two isoformsAdipoR1 and AdipoR [44]. It also inhibits the excretion of the vascular cell adhesion molecule 1 (VCAM-1), endothelial-leukocyte adhesion molecule 1 (ELAM-1), and intracellular adhesive molecule 1 (ICAM-1) on vascular endothelial cells. Johns Hopkins neuroscientist Mark Mattson has studied intermittent fasting for 25 years. INTERHEART Study Investigators. 1John 1:9. Improvements in Coronary Heart Disease Risk Indicators by Alternate-Day Fasting Involve Adipose Tissue Modulations. Moreover, the IF diet presents a useful substitute to obese/overweight patients who find the CER diet difficult to maintain [12]. The interventional group ate 100% of their energy needs during an 8 h eating window each day with their caloric intake divided into three time-points (1 p.m.; 4 p.m.; 8 p.m.). Its concentration is elevated in obese people, and is correlated with body mass index (BMI), total cholesterol, triglycerides, blood pressure, and inflammation markers. Cardiovascular disease development is also predisposed with cardiac hypertrophy. Potential benefits and harms of intermittent energy restriction and intermittent fasting amongst obese, overweight, and normal weight subjectsA narrative review of human and animal evidence. It also reduces the risk of type 2 diabetes [9]. Journal of Cardiovascular Development and Disease. Hoddy K.K., Gibbons C., Kroeger C.M., Trepanowski J.F., Barnosky A., Buhtani S., Gabel K., Finlayson G., Varady K.A. Heart Disease and Stroke Statistics2018 Update, A Report from the American Heart Association. Burnett M.S., Lee C.W., Kinnaird T.D., Stabile E., Durrani S., Dullum M.K., Devaney J.M., Fishman C., Stamou S., Canos D., et al. Some organisms in the periods where they lack access to food are dormant, for example, yeasts entering the stationary phase [18]. 2019; doi:10.3390/nu11030673. Hypertension: Practice Essentials, Background, Pathophysiology. Meals should be varied, similar to the Mediterranean diet. Carotenoids and cardiovascular risk. The eating of red meat, sweetened beverages, and excessively salty foods (daily salt intake < 5 g) should be avoided [5,7]. Trepanowski J.F., Kroeger C.M., Barnosky A., Klempel M.C., Bhutani S., Hoddy K.K., Gabel K., Freels S., Rigdon J., Rood J., et al. The ACCORD trial confirmed greater risk of cardiovascular events during the presence of hypoglycemia in both older and younger individuals [98]. One of the modifications is the use of the IF diet. provided a single-center randomized clinical trial of obese individuals (mean BMI = 34) to compare the effects of ADF to daily calorie restriction on weight reduction, weight maintenance, and CVD risk predictors [66]. That is why living organisms have developed many adaptive mechanisms that allow them to survive periods of famine. It makes sense, but in some cases, its wrong. Most of the studies are having a hard time making cholesterol corroborate with cardiovascular disease. Garlic, olive oil, and other plant-based foods can also help reduce inflammation. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Theaflavin reduced the atherogenicity index, in addition to also ceasing alanine transaminase and hepatic lipase activity [87]. Energy is contained within stored adipocytes, which under certain conditions is released from them under the influence of enzymeslipases [21]. Most evidence supporting the connection between obesity, overweight, and cardiovascular disease (CVD) incidences are based one-time-point measurements. He said, stents to open up the arteries were placed the next day, and he went home. The concentration of ketones is low, because glycogen stores in the liver are not depleted [19]. Schmidt S., Willers J., Stahl F., Dardano A., Penno G., Del Prato Mutz K.O., Scheper T., Hahn A., Schuchardt J.P. Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation. Heart disease in women: Understand symptoms and risk factors, Heart-healthy diet: 8 steps to prevent heart disease, Implantable cardioverter-defibrillators (ICDs). Additionally, this diet reduces the triacylglycerol levels as the result of decreased gene expression responsible for triacylglycerols synthesis (MOGAT3, MOGAT2, and DGAT1). NSAIDs: Do they increase my risk of heart attack and stroke? For that, she said it should be avoided when praying for breakthroughs. Changes in these parameters limit the risk of developing coronary heart disease (CHD) [25]. The symptoms of peripheral artery disease, where arteries are beginning to harden in the legs and arms, include numbness, tingling, pain, and infections. The above-mentioned diets can be successfully used in people who want to reduce their weight to improve their health, but can also be implemented in a population of patients in whom obesity is an important risk factor for the development of type II diabetes [10]. showed that in hemodialyzed patients, administration of zinc may induce a higher activity of paraoxonase enzymes [93]. Lopez-Jimenez F (expert opinion). The basic working principle of Open-FOAM is the Finite volume method, and it flawlessly provides the numerical solutions of coupled Partial differential equations. It is a serious problem of pathogenicity and mortality in both developed and developing countries. Patikorn C, et al. The subtype of the IF diet is the ADF diet (alternate day fasting). http://creativecommons.org/licenses/by/4.0/, https://www.who.int/cardiovascular_diseases/en/, http://bip.stat.gov.pl/organizacja-statystyki-publicznej/rzadowa-rada ludnosciowa/publikacje-rzadowej-rady-ludnosciowej/, https://emedicine.medscape.com/article/241381-overview. Additionally, the fasting window may be planned during nighttime. In the studies conducted on humans and on animal models, the beneficial effect of the IF diet on body weight and glycemic parameters was proven. Sutton E.F., Beyl R., Early K.S., Cefalu W.T., Ravussin E., Peterson C.M. Moreover, there were no significant differences between the ADF and CR groups in terms of heart rate, blood pressure, fasting glucose, fasting insulin, triglycerides, and CRP at both time-point assessments [66]. The European Union on Tuesday extended a 610 million euro ($647.15 million) grant to Serbia for the construction of a fast railway line that will connect southern Serbia with central Europe. The mechanism of the pressure drop may be associated with an increase in parasympathetic activity due to the brain-derived neurotrophic factor (BDNF), increased norepinephrine excretion through the kidneys, and increased sensitivity of natriuretic peptides and insulin [22]. As a result, it has cardio-protective and anti-sclerotic effects. In addition, excessive restriction of calories causes dysregulation of hormone management. These diets are not specific to artery unclogging, as you can see you can implement other good habits when it comes to food to help reduce plaque formation in the arteries. Anastasiou C.A., Karfopoulou E., Yannakoulia M. Weight regaining: From statistics and behaviors to physiology and metabolism. Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. The study group consisted of 1422 people who were subjected to one-year follow-up during the IF diet [22]. contributed to data analysis, interpretation of findings, and drafting the article. 16:8, consisting of a 16-h fast, and then an 8-h nutritional window. Aug. 19, 2022. This is accompanied by a bad mood at the beginning of the diet, such as fatigue or dizziness, because the body needs time to get used to using ketones instead of glucose. Chronic high fat diet induces cardiac hypertrophy and fibrosis in mice. Skipping breakfast and the risk of cardiovascular disease and death: A systematic review of prospective cohort studies in primary prevention settings. Less insulin in the body will then means fewer risks of lesion or cracks in your arteries. The development of atherosclerotic plaque is caused by vascular endothelial dysfunction and long-term exposure to cardiovascular disease development factors. PRAYER POINTS: 1. It is necessary to give full play to comparative advantages, accelerate the digital transformation of different types of industries, improve the quality and efficiency of economic development, and transform development opportunities and growth potential into tangible results and benefits. Allaf M, et al. Coronary artery spasm: Cause for concern? Risk factors may include high cholesterol and triglyceride levels, high blood pressure, smoking, diabetes, obesity, physical activity, and eating saturated fats. The .gov means its official. Schmidt et al. Jankowski P. Principles of cardiovascular disease prophylaxis in 2018. By altering the levels of these adipokines, it inhibits the adhesion of monocytes to vascular endothelial cells, neutrophils, and macrophage pro-active activity, and platelet aggregation. For that, she said it should be avoided when praying for breakthroughs. The use of an IF diet has a beneficial effect on lowering blood pressure. Decreased apoptosis of B cells under the influence of diet was also observed in mice with type 2 diabetes [75]. Exercise has a cascading effect that helps with a variety of conditions that lead to clogged arteries. Father, I thank You for the gift of life through the death of our Lord Jesus Christ. Fasting diet: Can it improve my heart health? Intermittent fasting has become popular for people who wish to maintain or lose weight. It has long been known about garlics health-promoting effects. The particularly positive effects of IF diets were observed in patients with type 2 diabetes. It has pro-inflammatory activity [53]. Benefit from the use of the IF diet were confirmed in research on the development of atherosclerosis. Short-term Regulation of Resistin in vivo by Oral Lipid Ingestion and in vitro by Fatty Acid Stimulation. Remember that a heart-healthy diet and regular exercise can improve heart health. Additionally, it should be attempted for a maximum of 12 weeks (continued continuously or intermittently) [10]. Abbreviations: NS-non significant. Cardiac catheterization in Trumbull Regionals Cath Lab showed two arteries 99 percent blocked. However, smoking, obesity, lack of physical activity, disorders of lipid metabolism, hypertension, diabetes, and poor diet are among the modifiable factors [4]. Omega-3 fatty acids, which are found in fish, nuts, and avocados, can help reduce inflammation in the arteries. Youve probably heard that you shouldnt eat fat to prevent the clogging of arteries, as I mentioned before, fat has nothing to do with cardiovascular disease. 2019; doi:10.3390/jcdd6030030. But it does come with challenges and side effects, among which having a dry How Often Should You Intermittent Fast on Keto? Ciccone M.M., Scicchitano P., Gesualdo M., Zito A., Carbonara S., Ricci G., Cortese F., Giordano P. The role of omega-3 polyunsaturated fatty acids supplementation in childhood: A review. The side effects of intermittent fasting aren't well known. Wan R., Weigand L.A., Bateman R., Griffioen K., Mendelowitz D., Mattson M.P. Wan R., Ahmet I., Brown M., Cheng A., Kamimura N., Talan M., Mattson M.P. Toledo F.W., Grundler F., Bergouignan A., Drinda S., Michalsen A. Over time, plaque and inflammation can narrow and harden the arteries. The rats were fed black tea extract containing highly purified mixtures of theaflavins at the same time. Ouchi N., Kihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., Hotta K., Nishida M., Takahashi M., Muraguchi M., et al. The authors declare no conflict of interest. The study proved the reduction of SBP and DBP in groups of people who fasted for a long period of time. If the arteries become blocked or narrowed due to heart disease, a person may be at risk of a heart attack. Thus, it may help athletes to achieve the desired body mass for a specific sport category. Mattson M.P., Moehl K., Ghena N., Schmaedick M., Cheng A. Abbreviations: NS, not statistically significant (p > 0.05); IL6, interleukin 6; CRP, C-reactive protein; TNF, tumor necrosis factor ; Only studies from the past 10 years with full data published were considered. Biochemistry of Lipids, Lipoproteins and Membranes. Dardano A., Penno G., Del Prato S., Miccoli R. Optimal therapy of type 2 diabetes: A controversial challenge. It has a pro-atherogenic effect. Typically, you can eat whatever foods you like. When practicing one of those diets, you will help improve your metabolism as well as reduce insulin levels in the body. [(accessed on 1 February 2019)]; Grodstein F., Manson J., Stampfer M. Hormone therapy and coronary heart disease: The role oftime since menopause and age at hormone initiation. Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects. Calixto A. Oxidized cholesterol is a key component of the plaque that clogs arteries, and these vitamins help reduce its formation. I compile in this blog informations, studies, content, etc. These studies were carried out on rats assigned to groups with an ad lib diet and with IF for 3 months. Expression of the molecules was measured by ELISA (enzyme-linked immunosorbent assay). Resistin increases the expression of chemotactic monocyte 1 protein (MCP-1) and sICAM-1 in vascular endothelial cells. What are its benefits? Additionally, it was observed that participants in the ADF group ate more than was prescribed on fast days, and less than prescribed on feast days, while the CR-group followed their prescribed goals without disturbances. B.M., K.Z. In contrast, mammals have liver and adipose tissue. Only studies from the past 10 years with full data published were considered. This disease is the accumulation of cholesterol-laden plaque inside the arteries nourishing your heart, a process known as atherosclerosis. However, with atropine, the heart rate significantly increased in wild-type mice compared to the mutant mice. Another protocol consists of a 24-h fasting period, alternated with a 24-h eating period, repeated two or three times a week. Harvie M.N., Wright C., Pegington M., McMullan D., Mitchell E., Martin B., Cutler R.G., Evans G., Whiteside S., Maudsley S., et al. Research carried out by Bhutani et al. Several research studies have shown that aggressively lowering your LDL or "bad" cholesterol below 100 can actually open up blocked coronary arteries, at least partially. Weight change over the intervention phase was 7.1% 0.7% (mean SEM) with ICR, 5.2% 0.6% with CCR, and 3.3% 0.6% with the control regimen (poverall < 0.001, pICR vs. CCR = 0.053). Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. According to the studies by Zhao et al., conducted on mice with apolipoprotein E deficiency, treatment with curcumin inhibits macrophage transformation in foam cells. Animals with an IF diet had a higher adiponectin concentration and the area of ischemia was smaller. There is an inverse correlation between plasma adiponectin levels and body weight. This fun fruit contains phytochemicals that act as antioxidants to protect the lining of the arteries The experiment was attended by 40 healthy participants with the correct body mass index (BMI) who fasted during Ramadan and 28 participants, respectively, selected in terms of age and BMI index who did not fast. The concentration of resistin significantly decreased after using the ADF diet, which probably was associated with a decrease in body weight [42]. Kozaki K., Kaminski W.E., Tang J., Hollenbach S., Lindahl P., Sullivan C., Yu J.C., Abe K., Martin P.J., Ross R., et al. Fluctuations in glucose concentration cause instability of the body, which results in an increased number of falls and frequent fractures due to osteoporosis [97]. Positive effects of intermittent fasting in ischemic stroke. The next impact keto, meaning low-carb high fat diet, will have on the plaques in your arteries might surprise you. Plaques comprise cholesterol, calcium, a blood-clotting protein Rahimi-Ardabili et al. More research is needed to determine whether regular fasting can reduce the risk of heart disease. Johnstone A. Fasting for weight loss. Mayo Clinic. This is followed by prevention of oxLDL binding to SR-A and increased outflow of ABCA1-dependent cholesterol [92]. WebIn addition to these lifestyle changes, there are also dietary supplements that may help unclog your arteries fast. Beshyah S.A., Hassanein M., Ahmedani M.Y., Shaikh S., Ba-Essa E.M., Megallaa M.H., Afandi B., Ibrahim F., Al-Muzaffar T. Diabetic Hypoglycaemia during Ramadan Fasting: A Trans-National Observational Real-World Study. After observation, a decrease in glucose concentration, an increase in insulin in plasma, a decreased HOMA index, and an increase in the number of pancreatic B-cell cells in streptozotocin-induced rats on the IF diet [74] were observed. Improvement of metabolic parameters inhealthy older adult men following a fasting calorie restriction intervention. The IF diet has also had a beneficial effect on the prevention of stroke. Todays Prayer Points: Prayer Points For Open Heavens 28 February 2023. While the body is abstaining from food, the concentration of glucose, which is the basic energy substrate, decreases. 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