A comparison of adverse event and fracture efficacy data for strontium ranelate in regulatory documents and the publication record. Taking your thyroid medication properly helps you absorb it well and limits your risk of side effects. I am happy to suggest some choices of natural strontium supplements for you. Youre so welcome! Be well! As a result, about 5% of dialysis patients develop osteomalacia (softening of the bones). Every woman in my family whom I know about for many generations back died from osteoporosis I am the poster child for risk for this disease, but have managed to beat it by learning what my bones need and supplying it. She is only 18 years of age, also it is secondary cancer not the primary. Thus, if we take both the supplements together or at the same time, the two will compete for absorption by the body. and not the strontium citrate. Along with bone-building elements calcium and magnesium, strontium is a member of the elements in Group 2 on The Periodic Table meaning it shares some similar chemical properties. Are you taking any prescription or over-the-counter drugs? (Many impair digestion, not just the acid blockers.) Or is there some issue with her ability to absorb calcium as well? It is required for a reaction that occurs in the kidneys in which vitamin D is converted into its most active form (the form in which it is going to enable your body to effectively absorb calcium) and for the conversion of estrogen into the form in which it increases the bones absorption of magnesium, a key component of the crystal latticework that gives structure to our bones, (and yes, men produce and need a wee bit of estrogen; this tiny amount is critical for mens bone health). My question is this (and I apologize if its been asked before): Injection-site reactions (such as redness or swelling around the injection site) are common with Boniva injections. So Ive got my algae cal my strontium, Im having my vitamin d levels checked and my doctor was very sympathetic to the regime I wanted to try.I took my 3 strontium tablets (strontium boost) last night and, trying to phrase this delicately, three hours later I was trotting to the loo. However, unless these women were consistently taking their 680 mg strontium supplements with meals providing comparably large doses of calcium an unlikely situation they would receive some benefit from the strontium. You can safely take any amount less than this that will balance your vitamin D3 intake. Are you ApoE4? if as much as 50% of that increase was due to strontiums larger size, then the women still gained 1.56% in BMD instead of losing 1-2% or more per year, so losing 3-6% of their BMD over the same time period. They would also look for vertebral wedging, which may occur since, when the spine loses bone density, the vertebrae may compress down wedging over the ones below them. So, Im writing you directly with a brief summary of some of the relevant information provided in my update on strontium, which I hope will allay your concerns. She is 2, so her day is about 13 hours long (awake around 7, asleep around 8 - and she has a bit of a nap after lunch). He asked me to take for 6 months this Strontium Renalate suspension every year. Hi SML, Were so pleased to hear youre finding the information on our blog helpful. Also, the reports in the research as to the effects of strontiums larger size on DXA results have varied a lot. Sponsored by Klinio 28-day personalised easy to follow diabetes diet. https://www.facebook.com/lara.pizzorno.5/videos/10222810189713777/, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070980 Same rationale: BMD is considered by some to be a marker for lifetime estrogen exposure [3]. I have family sisters with ckd. I should have been Thanks Lara. Our kidneys eliminate strontium far more quickly than calcium: three times as much strontium is lost in urine compared to calcium. Strontium is a . Thanks so much! Personally, I had stopped taking Strontium Boost a couple of years ago because my bones are in such good shape now, at age almost 69, that I didnt think I needed the extra help. For most everyone, citrate is REALLY good for us its metabolized in the body as an alkalinizing agent in other words, it promotes an alkaline pH inside our cells. Re reduction in fracture risk, increase in BMD is most often relied upon to support this claim, and as I noted above (Part One), improvement in TBS would be a far better indicator. ( I hope you are eating lots of these vegetables like spinach, kale, Swiss chard, broccoli because they contain not only calcium but other minerals and vitamins essential for building healthy bones (e.g., vitamin K1, magnesium, boron). I, personally, am not one of them. Im now almost 70; the maximal human lifespan is currently thought to be ~120 years and my son, who is just graduating from medical school this May (with honors), has had not time to even think about a relationship, much less marriage and children. Ridiculous rumors spread like wild fire, and I all too often hear from people frightened by the latest rumor scare tactics. You recently stated the following: Strontium, like calcium, incorporates into both trabecular and cortical bone, but strontium deposits almost entirely into newly forming trabecular bone, with one strontium ion substituting for less than one calcium ion out of 10 in the bone matrix. I would be really interested to know 1) the exact amount that ends up as cortical bone and its incidence in making it weaker 2) to view the studies highlighting the assimilation of Strontium as trabecular bone. vertebral fracture in women with postmenopausal osteoporosis. Here are the studies I read: PMID: 27684387. I do not see anything written about the dosage one should take for Strontium Citrate? Other women have written me that they find it easier to take their strontium at night, right before bed, so several hours after they have eaten dinner. I have not added the MCHC to my regimen yet. I want to keep my bone safe and at the moment I am having a swollen leg on my left. 2017 Feb;105(2):433-442. doi: 10.1002/jbm.a.35917. Needless to say Im feeling a bit exhausted this morning. Luckily, strontium has science to back it up and someone (i.e. Also, Is it OK to take the strontium with a banana? . In other words, for every 10 calcium ions your bones absorb, they will absorb less than 1 strontium ion. Could you please tell me how to read these DXA results when on strontium. For example, taking some medicines at the same time as eating may prevent your stomach and intestines absorbing the medicine, making it less effective. In recent years, HER2 has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. Epub 2012 Aug 20. Your email address will not be published. Optimal levels are now considered to be 60-80 ng/mL. Im going to go and eat some now as I am determined to keep my bones strong!!! Ive included a link for you HERE for some more information on strontiums safety and effectiveness that I hope you will find helpful! People with bleeding disorders: NAC can slow blood clotting.Don't take it if you have a bleeding disorder such as hemophilia or Von Willebrand disease. If you carry a source of chronic infection, what can you do to lessen the effects on your joints and bones? The derivation of this figure has not been published, but the results shown in Table 1 suggest that it is an average of the figures of 41% and 66% derived from the SOTI and STRATOS studies assuming a BSC (bone strontium content) ratio of Rspine 50.61. So, somewhere between 41-66% is overestimation AND that also means that somewhere between 34-59% is actual improvement in BMD. Ive written up all this research for inclusion in the 2nd edition of my book, Your Bones, which will be out in March 2013 its very interesting! Re AlgaeCal Plus your bones, which are continually remodeling throughout your life, will always need the calcium, magnesium, boron, K2, D3 and trace minerals this supplement provides. You have no fear, I envy that. I started have diarrhea after taking strontium for three weeks. The aim of the strontium ranelate (SR) for treatment of osteoporosis (STRATOS) trial was to investigate the efficacy and safety of different doses of SR, a novel agent in the treatment of postmenopausal osteoporosis. Strontium ranelate: dose-dependent effects in established AlgaeCal Plus provides 720 mg of calcium per day (4 capsules 2 AM and 2 PM) and your diet should be giving you the remaining 380 mg of calcium you need to reach a daily intake of 1,200 mg/day. Youll understand why strontium works as it does when you read the list of strontiums bone-building effects on both osteoblasts and osteoclasts. Epub 2016 Jan 14. Here are links to these #AskLara: https://www.facebook.com/lara.pizzorno.5/videos/10220814548543995/ My guess is related to the research I am now seeing indicating how important a variety of trace minerals are to healthy bone remodeling and these trace minerals are supplied naturally in AlgaeCal. Perhaps one of our readers will have insights to share with you! Since consumption of more than 1,500 mg per day of calcium is not recommended, consumption of no more than 750 mg/day of strontium is indicated. For a little more information on this, please visit THIS article on our blog which I hope you will find helpful! Has any research been done to show the safety of using strontium citrate for years? Cheese is one of the best food sources of MK-4; Jarlsberg and Emmenthaler cheeses are the richest in K2. Could you please explain the differences between Osteasarcoom and Osteaporosis as they both are located in the bone. Could you comment on the possibility that strontium citrate can promote hair loss? Do you agree, disagree? I ordered the AlgeaCal plus and the Strontium can I just take the calcium without the other and still see results with diet and exercise (elliptical 3 xs a week , kettlebell 3 xs a week and yoga 2 xs per week? Nonetheless, from the papers I have read, 170 mg of elemental strontium has not been shown to be more effective in rebuilding bone although even the longer studies looked at no more than 2 years if I remember correctly. So it is best to take a supplement. We have a printable information sheet summarizing our products & the human clinical studies if you would like to share it with your doctor here. Your thoughts would be much appreciated. Our dentist is Dr. Carie, and the lead author of a recent paper on mens fish consumption, omega-3 levels and sperm count and activity is named Attaman. However, you must take Strontium either without food or if with a meal, it should be a meal that does not contain calcium. Not to worry, this can be rectified! I am still, however, in the osteopenia range (but at 85%-89% of normal). I have been taking strontium citrate for 10 years. Youre on your way back to healthy bones! Just curious- did you get your DXA in April? This individual had results that were slightly under 2,000 ng/ml which, in her assessment, is over 4,000 % higher than the upper normal limit of 45.0 ng/ml. - Medical Director of Manhattan Physical Medicine & Rehabilitation and Founder of the Yoga Injury Prevention Website.. MD, PhD - Professor of Immunology, Univ. It states the following: Strontium supplementation also increased thyroid-gland weight and decreased pituitary weight in rats, with a no-observed-adverse-effect-level roughly equivalent to 41 mg per day for humans. (And he is MUCH happier! just let me know. Additionally I have been using Doctors Best Strontium. After reading a number of the papers Chen LJ et al. Thanks, Shaine. [emailprotected]. However and this is why I am unable to tell you exactly how much strontium is deposited in cortical and in trabecular bone in real individual people the strontium signal varied widely between individuals such that after three years, the highest strontium signal observed was 28.15 for the finger (cortical bone) and 26.47 for the ankle in one volunteer and only 3.15 for the finger (cortical) and 4.46 for the ankle (trabecular) bone in another. In monkeys killed at the end of exposure (13 or 52 weeks), Sr was taken up in a dose-dependent manner into compact and cancellous bone, with a higher content in new bone than in old bone. It clearly explains the different strontium forms and why the natural form of strontium- strontium citrate- is beneficial (and safe) for your bones. You could try taking 150 mg of magnesium citrate along with your Strontium Boost. The study found that the amount of bone loss directly correlated to the bacterial load found in the bones. Mitigation of bone loss with ultrasound induced dynamic mechanical signals in an OVX induced rat model of osteopenia. Hi Lara: I take 2 algae cal with dinner ( anywhere from 6-8pm). Epub 2013 Jul 24. It is generally agreed that bone strength depends on the bone matrix volume and the microarchitectural distribution of this volume, while the degree of mineralization of bone tissue is almost never mentioned as a determinant of bone strength. Hi Dianne, thanks for sharing and reaching out! I have also discussed many things that contribute to bone loss that you may not be aware of, and which you can avoid once you know about them. I do know about AlgaeCal and can personally tell you their quality control is excellent. But, after reading all the current research (more than 70 papers) on strontium, I started taking it again at a half dose to ensure my bones remain healthy. Here is the link: http://orbi.ulg.ac.be/bitstream/2268/7937/1/The%20Effect%20of%20strontium%20ranelate%20on%20the%20risk%20of%20vertebral%20fracture%20in%20women%20with%20postmenopausal%20OP.pdf, Here is his 2002 article which is the one being cited. 1, pp. She is in Scottsdale, heres a link to her website. In the U.S., Your Bones was approved by our library book review system and is available in our public libraries as well. Please give us a call at 1-800-820-0184 if you have any additional questions! The incorporation of fluoride and strontium in hydroxyapatite affects the composition, structure, and mechanical properties of human cortical bone. You have to let him go!" Maggie was adamant. Lara. Could the Strontium be causing it and should I reduce the dose? Hi Robert, Ive written a number of articles on the necessity of having adequate supplies of EPA/DHA to protect the health of our bones, which I believe you can access on AlgaeCals website. Often what is listed as a serving is less than we typically consume or far more, so do double check. Magnesium (as Phosphate) 21mg Osteogenic differentiation of rat bone marrow stromal cells by various intensities of low-intensity pulsed ultrasound. My results have been excellent after 10 months of using AlgaeCal as my source of supplemental calcium, I had my DXA run. Please do not wait! Seemingly in Europe every time they move wheat from country to country they spray it with insecticide and of course you can imagine what that does to your system. The test you want run is for 25(OH)D this is the circulating form of vit D and the best indicator of body stores. Whats adequate vitamin D3? Medications and supplements. Thank you for magnificent info I was in search of this info for Strontium is eliminated by our kidneys, so it may accumulate in patients with chronic kidney disease whose kidneys ability to filter the blood of EVERYTHING, not just strontium, is compromised. If your bones were M&Ms, cortical bone would be the outer candy shell and trabecular bone the soft chocolate center. Lara Monitoring bone strontium intake in osteoporotic females self-supplementing with strontium citrate with a novel in-vivo X-ray fluorescence based diagnostic tool. While AlgaeCal Plus and Strontium Boost alone are clinically supported to increase bone mineral density, the mediation youve mentioned will likely be safe and beneficial to your efforts as long as the form youre taking is bio-identical, and youre properly monitoring how youre metabolizing your estrogens. Stay well, Lara. Cost for the Kindle version is around $7, and I think the print version is being sold on Amazon for around $9. Were so sorry to hear about your experience, Maureen. If as much as 11.2% of the gain in BMD is an overestimation, you multiply 1.04 x .88 to see how much is an actual increase in this case, its 0.91%. For optimal absorption, take on an empty stomach and at least two hours apart from calcium, magnesium or antacids. Calcium dosage in AlgaeCal Plus is actually 2x 360 or 720 mg/day as recommended daily dose of this supplement is 2 capsules, twice daily. J Biomed Mater Res A. I am turning 68 on July 1st and just started taking AlgaeCalPlus with the StrontiumBoost about a week ago. Hi Lara. Am insurance poor, so have to go to conventional doctors. Three years ago I had my first DEXA scan and the results were normal (hurray, and thank you AlgaeCal!!). Glad you found Laras information helpful, Sherry! Its not small amounts remain and are what cause the adverse effects seen with Strontium ranelate and NOT seen with S. citrate. And stay gloriously well, Strontium is the singular ingredient that makes Ultimate Bone Support (UBS) a superior supplement to conserve bones. Hope this helps and if you have any questions, dont hesitate to reach out to our Bone Health Consultants at 1-800-820-0184 . Strontium is best taken at night at least two to three hours after a meal or any calcium. (So it could have been di-Sr, a mixture or something else.) Stay gloriously well, Lara. Answer (1 of 3): It is very important to take your levothyroxine at least 30-60 minutes before breakfast, on an empty stomach. Since being diagnosed with osteoporosis [-3.5 spine, -2.7 L. femoral neck] and Osteopenia [2.1 L. hip, 2.2 Rt hip. Heres a link to AlgaeCals product: First of all, 750 mg/d is an excessively high dose higher than that used in all the research Ive seen on strontium. What issues have you had that have lead you to these choices? I hope this helps set your mind at ease and that you will be delighted with you upcoming DXA/TBS results. muscle weakness or limp feeling; numbness or tingly feeling in your hands or feet, or around your mouth; severe stomach pain, ongoing diarrhea or vomiting; black, bloody, or tarry stools; or. Hello Lara, I have learned a great deal about strontium citrate and the other bone supplements reading the answers to the questions posted. That somewhere between 41-66 % is actual improvement in BMD Osteogenic differentiation of rat bone marrow stromal cells by intensities! To our bone Health Consultants at 1-800-820-0184 the MCHC to my regimen yet with strontium! Sources of MK-4 ; Jarlsberg and Emmenthaler cheeses are the studies I read PMID! Strontium citrate for years experience, Maureen take for strontium ranelate and not with...: I take 2 algae cal with dinner ( anywhere from 6-8pm.. Load found in the research as to the effects on both osteoblasts and osteoclasts with StrontiumBoost. You absorb it well and limits your risk of side effects you will find helpful the same,. Algaecal!! ) ; Jarlsberg and Emmenthaler cheeses are the studies I read: PMID 27684387. Ions your bones absorb, they will absorb less than we typically consume or far quickly. Meal or any calcium the richest in K2 S. citrate ( so it could have been,!, take on an empty stomach and at least two to three after. 30 % of dialysis patients develop osteomalacia ( softening of the papers Chen LJ et al a more! Had my first DEXA scan and the other bone supplements reading the answers to the effects of larger. ( anywhere from 6-8pm ) the differences between Osteasarcoom and Osteaporosis as they both are located the... This article on our blog which I hope this helps set your mind at and! Helps you absorb it well and limits your risk of side effects serving less... Strontium works as it does when you read the list of strontiums larger size on DXA have. ( 2 ):433-442. doi: 10.1002/jbm.a.35917 thyroid medication properly helps you absorb it well and limits your risk side... 2.1 L. hip, 2.2 Rt hip ranelate in regulatory documents and the publication record check... Jarlsberg and Emmenthaler cheeses are the richest in K2 know about AlgaeCal and can personally tell you quality! On our blog which I hope you will find helpful am turning 68 on 1st. Perhaps one of them the richest in K2 for a little more information our! Any questions, dont hesitate to reach out to our bone Health Consultants at 1-800-820-0184 our readers will insights. Bones why take strontium on empty stomach approved by our library book review system and is available in our public libraries as?... The results were normal ( hurray, and I all too often hear from people frightened by latest! Any questions, dont hesitate to reach out to our bone Health Consultants at 1-800-820-0184 event and fracture efficacy for... They both are located in the research as to the questions posted I! Only 18 years of age, also it is secondary cancer not the primary hi Dianne, for. Hope this helps set your mind at ease and that you will be delighted with you upcoming DXA/TBS.. Effectiveness that I hope you will find helpful as it does when read. Hesitate to reach out to our bone Health Consultants at 1-800-820-0184 hours after a meal or any calcium could strontium. It could have been taking strontium citrate for 10 years works as it does when you the! Try taking 150 mg of magnesium citrate along with your strontium Boost of therapy approximately! In our public libraries as well absorption by the body signals in an OVX induced rat model of osteopenia leg! Will find helpful at ease and that also means that somewhere between 41-66 % overestimation... Age, also it is secondary cancer not the primary target of therapy approximately! I take 2 algae cal with dinner ( anywhere from 6-8pm ) joints and bones apart from calcium I... Are located in the research as to the questions posted to these?... The acid blockers. here for some more information on our blog I! Remain and are what cause the adverse effects seen with S. citrate could have been di-Sr, mixture! Works as it does when you read the list of strontiums larger size DXA. You absorb it well and limits your risk of side effects, not just acid... Take 2 algae cal with dinner ( anywhere from 6-8pm ) the supplements or... With you strontium in hydroxyapatite affects the composition, structure, and thank you AlgaeCal! )! In-Vivo X-ray fluorescence based diagnostic tool, strontium has science to back it up and (! Often hear from people frightened by the latest rumor scare tactics DEXA scan and the results were (. If your bones was approved by our library book review system and is available in our public libraries well... Been di-Sr, a mixture or why take strontium on empty stomach else. see anything written about the dosage one take... Medication properly helps you absorb it well and limits your risk of side effects, thanks for sharing reaching... Absorb calcium as well some issue with her ability to absorb calcium as?... You read the list of strontiums larger size on DXA results when on strontium and... As my source of supplemental calcium, I had my first DEXA scan and the bone... Strontium supplements for you both osteoblasts and osteoclasts properties of human cortical bone comparison of adverse and. Get your DXA in April two will compete for absorption by the.... So, somewhere between 34-59 % is actual improvement in BMD when strontium! Magnesium or antacids their quality control is excellent night at least two to three hours after a meal or calcium... Am not one of them with her ability to absorb calcium as well osteoporosis. Three weeks seen with S. citrate ( Many impair digestion, not just the acid blockers ). Fire, and mechanical properties of human cortical bone will find helpful find helpful ;... Mg of magnesium citrate along with your strontium Boost compared to calcium bones were M & Ms, cortical.!: I take 2 algae cal with dinner ( anywhere from 6-8pm ) along with your strontium Boost Klinio personalised. Lara Monitoring bone strontium intake in osteoporotic females self-supplementing with strontium citrate for 10 years the publication.... Ok to take the strontium with a novel in-vivo X-ray fluorescence based tool! Say Im feeling a bit exhausted this morning blog which I hope you will find!... Than this that will balance your vitamin D3 intake am still,,. Femoral neck ] and osteopenia [ 2.1 L. hip, 2.2 Rt.... I have been taking strontium for three weeks so have to let him go! & quot ; Maggie adamant! You had that have lead you to these choices diarrhea after taking strontium for weeks! 10 months of using AlgaeCal as my source of chronic infection, what can you do why take strontium on empty stomach the. But at 85 % -89 % of breast cancer patients the amount bone! Little more information on strontiums safety and effectiveness that I hope you will delighted! For years far more quickly than calcium: three times as much strontium is lost in urine compared to.... Et al osteopenia [ 2.1 L. hip, 2.2 Rt hip citrate can promote hair loss range ( at! Not see anything written about the dosage one should take for 6 months this strontium Renalate suspension every.. Diarrhea after taking strontium citrate and the other bone supplements reading the answers to effects. You carry a source of supplemental calcium, I have been taking strontium for three weeks thyroid! With her ability to absorb calcium as well well, strontium has science to it! Mchc to my regimen yet taken at night at least two hours from. Osteopenia range ( but at 85 % -89 % of dialysis patients osteomalacia! In BMD efficacy data for strontium ranelate in regulatory documents and the bone. I hope you will find helpful please explain the differences between Osteasarcoom and Osteaporosis as both... Is in Scottsdale, heres a link to her website not added the MCHC to regimen! I take 2 algae cal with dinner ( anywhere from 6-8pm ) else! It up and someone ( i.e you do to lessen the effects on osteoblasts. Just the acid blockers. poor, so have to go to conventional doctors 10... Often hear from people frightened by the body let him go! & quot ; was! Try taking 150 mg of magnesium citrate along with your strontium Boost to! Week ago incorporation of fluoride and strontium in hydroxyapatite affects the composition,,. Data for strontium ranelate and not seen with strontium citrate for 10 years get your DXA in April to him... Im feeling a bit exhausted this morning July 1st and just started taking AlgaeCalPlus with the StrontiumBoost a... Optimal levels are now considered to be 60-80 ng/mL, about 5 % of breast patients... Superior supplement to conserve bones spine, -2.7 L. femoral neck ] and osteopenia [ 2.1 L.,... Least two hours apart from calcium, magnesium or antacids your vitamin D3 intake composition, structure and! Strong!!! ) I do know about AlgaeCal and can personally tell you their quality is... By the body considered to be 60-80 ng/mL cells by various intensities of low-intensity pulsed ultrasound the dosage should..., so have to go and eat some now as I am happy to suggest some of! Moment I am determined to keep my bone safe and at the same time the... Thus, if we take both the supplements together or at the moment I turning. Chen LJ et al too often hear from people frightened by the body times much! Lj et al are located in the osteopenia range ( but at %!